Publication Synopsis

Gene expression changes associated with progression and response in chronic myeloid leukemia.

The goal of the study was to determine the changes in gene expression and molecular pathways that occur during the progression of chronic phase to advanced phase chronic myeloid leukemia. DNA microarray analysis was performed to identify gene expression profiles of chronic, accelerated, and blast phases of chronic myeloid leukemia. IPA’s Canonical Pathways feature enabled the researchers to identify the important role of the WNT/beta-catenin signaling pathway during chronic myeloid leukemia (CML) progression from the chronic phase to advanced phase. They found that 16 genes associated with the WNT/beta-catenin signaling pathway were among the genes that were dysregulated specifically during CML progression.