Publication Synopsis

Identification of candidate genes associated with salivary adenoid cystic carcinomas using combined comparative genomic hybridization and oligonucleotide microarray analyses

Researchers studying adenoid cystic carcinoma (ACC) of the salivary gland identified genes for IPA using a two-step strategy based on comparative genome hybridization and microarray analysis. They focused on up-regulated ACC-associated genes on ACC-associated loci with increased DNA copy number. Using the IPA global functional analysis and network analysis features, the investigators discovered how a subset of these genes interact in a network of molecular functions related to cancer. Their study yields new and valuable information that contributes to our understanding of the molecular basis of ACC and may help identify possible targets for therapeutic intervention.