Using IPA to Analyze Illumina RNA-Seq Data Reveals Abundance-Specific Biological Signatures in Alzheimer’s Disease

Presented by: Darryl Gietzen, Ph.D., QIAGEN Silicon Valley | Duration: 33:44 minutes

IPA was used to interpret Alzheimer’s disease biology by comparing Illumina RNA-Seq data from Alzheimer’s disease (AD) and normal brain samples. This analysis revealed very specific biological changes in certain classes of transcript expression, demonstrating how the unique benefits of RNA-Seq can help characterize disease changes. See how IPA maximizes RNA-Seq data analysis, how grouping and analyzing all significantly changed genes in RNA-Seq data can provide pathway level information, and how the sensitivity and accuracy of RNA-Seq enables pathway analysis on a subset of genes to elucidate more subtle biological changes.