Distinct Gene Expression Profile of Regulatory T Cells in Prostate Cancer
The inhibitory role of regulatory T-cells (Tregs) in cancer is now well established. Furthermore, inhibition of Treg function has been shown both experimentally and clinically to improve the immune response towards a variety of cancers. Developing new and more effective strategies interfering with the function of Tregs in cancer requires a deep understanding of Treg suppressor machinery, and a thorough dissection of the molecular elements that orchestrate their differentiation from T cells. This work paves the way for a better understanding of Treg biology in the context of prostate cancer and offers potential new avenues for Treg manipulation toward improving the outcome of immunotherapy.