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West Nile Virus Case Study — Example of Infectious Disease Research Using Ingenuity Pathway Analysis (IPA)
Presenter: Jean-Noel Billaud, PhD.
Date: Dec 3, 2014
Time: 5:00 PM–6:00 PM (CET)
Duration: 1 hour
Infection by West Nile Virus is a worldwide public health concern, as it is the most common cause of epidemic viral encephalitis in USA. Yet the viral pathogenesis is not well understood. Datasets from 2 studies using different cell culture models (a microarray study on retinal pigment epithelial cells and RNAseq on primary macrophages) were uploaded and subsequently analyzed using Ingenuity Pathway Analysis (IPA) software. Features of IPA enabled us to shed light on canonical pathways, biological processes, and transcription regulators involved in West Nile Virus infection.
Jean-Noel Billaud, PhD joined Ingenuity Systems (now QIAGEN) in 2008 as staff scientist. He is now principal scientist for in silico research program in oncology and infectious diseases. Jean-Noel Billaud holds a PhD in Blood Cell Biology from Paris VII, and has done his post-doctoral work at the Scripps Research Institute (San Diego, CA).
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