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Science Spotlight

The Ingenuity Science Spotlight provides a closer look at how IPA has been used in published research. Click on the article title below to read a brief synopsis of the research or link to the article abstract.

2011

November 2011 Researchers used IPA to identify differences in candidate gene association between European ancestry and African American asthmatic children
July 2011 Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome.
May 2011 IPA was used to identify mechanism of action of small molecule compounds.
March 2011 Cyclooxygenase-2 network as predictive molecular marker for clinical pregnancy in in vitro fertilization.
January 2011 Differential Effects of Three Canonical Toxoplasma Strains on Gene Expression in Human Neuroepithelial Cells

2010

October 2010 Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways.
July 2010 Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes.
March 2010 Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells

2009

December 2009 Identification of Novel Cellular Targets for Therapeutic Intervention Against Ebola Virus Infection by siRNA Screening
September 2009 A Network Model of a Cooperative Genetic Landscape in Brain Tumors
March 2009 Clock-Cancer Connection in Non-Hodgkin's Lymphoma: A Genetic Association Study and Pathway Analysis of the Circadian Gene Cryptochrome 2.
February 2009 Differential NF-kappaΒ pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance.
January 2009 Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

2008

November 2008 Integrative Genomic Data Mining for Discovery of Potential Blood-Borne Biomarkers for Early Diagnosis of Cancer
June 2008 Proteomic Modeling for HIV-1 Infected Microglia-Astrocyte Crosstalk
June 2008 MicroRNA expression and identification of putative miRNA targets in ovarian cancer
May 2008 Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Independent Resistance to Aspergillus fumigatus in Alveolar Macrophages.
March 2008 Whole Genome Expression Profiling Reveals that Inhibition of Host Innate Immune Response Pathways by Ebola Virus can be Reversed by a Single Amino Acid Change in the VP35 Protein.
January 2008 Bioinformatic identification of FGF, p38-MAPK, and calcium signaling pathways associated with carcinoma in situ in the urinary bladder.
January 2008 Transcriptional Networks Inferred from Molecular Signatures of Breast Cancer.
January 2008 Computational methods for analysis of cellular functions and pathways collectively targeted by differentially expressed microRNA / Computational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer

2007

November 2007 Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1
October 2007 Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
August 2007 Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data
May 2007 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
April 2007 Underlying Mechanisms of Pharmacology and Toxicity of a Novel PPAR Agonist Revealed Using Rodent and Canine Hepatocytes
March 2007 Regulatory network of inflammation downstream of proteinase-activated receptors
February 2007 Identification of differentially activated cell-signaling networks associated with pichinde virus pathogenesis by using systems kinomics
January 2007 High Copper Selectively Alters Lipid Metabolism and Cell Cycle Machinery in the Mouse Model of Wilson Disease

2006 

October 2006 Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways
October 2006 Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus.
August 2006 Genetic networks responsive to sodium butyrate in colonic epithelial cells.
June 2006 Labor-Associated Gene Expression in the Human Uterine Fundus, Lower Segment, and Cervix
May 2006 Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of neurologically relevant genes.
March 2006 Gene expression analyses reveal molecular relationships among 20 regions of the human CNS.
February 2006 Gene expression changes associated with progression and response in chronic myeloid leukemia.

2005

September 2005 Identification of candidate genes associated with salivary adenoid cystic carcinomas using combined comparative genomic hybridization and oligonucleotide microarray analyses
August 2005 A network-based analysis of systemic inflammation in humans
August 2005 Combined Proteomics and Pathways Analysis of Collecting Duct Reveals a Protein Regulatory Network Activated in Vasopressin Escape
August 2005 Glucocorticoid Receptor-Dependent Gene Regulatory Networks
July 2005 Gene Expression Profiling of the Left Ventricles in a Rat Model of Intrinsic Aerobic Running Capacity.
July 2005 Temporal and spatial transcriptional programs in murine kidney development
July 2005 mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival
June 2005 Identification of Novel Candidate Oncogenes and Tumor Suppressors in Malignant Pleural Mesothelioma Using Large-Scale Transcriptional Profiling
June 2005 New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes
June 2005 AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes
May 2005 Anti-angiogenic activity of the mutant Dutch Aβ peptide on human brain microvasular endothelial cells
April 2005 Egr-2 and Egr-3 are negative regulators of T cell activation
February 2005 Identification of Transcriptional Networks during Liver Regeneration

2004

December 2004 Aquaporin-4 is increased in the sclerotic hippocampus in human temporal lobe epilepsy
August 2004 Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

 
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