Toxicology Content

A few highlights from the collection of toxicity pathways and lists in the Knowledge Base include:

  • Anti-Apoptosis Aryl Hydrocarbon Receptor Signaling
  • CAR/RXR Activation
  • Cholesterol Biosynthesis
  • Cytochrome P450 Panel – Substrate is a Fatty Acid
  • Cytochrome P450 Panel – Substrate is a Sterol
  • Cytochrome P450 Panel – Substrate is a Vitamin
  • Cytochrome P450 Panel – Substrate is a Xenobiotic
  • Cytochrome P450 Panel – Substrate is an Eicosanoid
  • FXR/RXR Activation
  • Glutathione Depletion – CYP Induction and Reactive Metabolites
  • Glutathione Depletion – Hepatocellular Hypertrophy
  • Glutathione Depletion – Phase II reactions
  • Hepatic Stellate Cell Activation
  • Hormone Receptor Regulated Cholesterol Metabolism
  • Hypoxia-Inducible Factor Signaling
  • LXR/RXR Activation
  • Mitochondrial Dysfunction
  • Negative APR Proteins
  • Oxidative Stress
  • Positive APR Proteins
  • PPARα/RXR Activation
  • Pro-Apoptosis
  • PXR/RXR Activation
  • RAR Activation
  • TR/RXR Activation
  • VDR/RXR Activation
  • Xenobiotic Metabolism