Discover Causal Connections. Faster.
IPA helps you better understand the regulatory mechanisms driving gene expression changes and their impact on diseases of interest through interactive visual exploration of causality between molecules and disease, function, or phenotypes. The newest release of IPA helps find trends and similarities across analyses using new heat maps for Downstream Effects, Upstream regulators, and Causal Networks.
Comparison Analysis enables visualization across multiple analyses with varying conditions such as dose response, time course, or other conditions to identify trends or similarities and differences between conditions. Using the new heat map for Canonical Pathway analysis, Downstream Effects, Upstream Regulators, and Causal Network Analysis, you can now answer questions like “are there transcription factors whose activity appears to increase with time (or dose) in my data?” and “are there clusters of biological functions that increase or decrease similarly across my different datasets?”
NEW! Find trends and similarities across analyses using new heat maps for Downstream Effects, Upstream regulators, and Causal Networks
Filter heat maps based on score (z-score or p-value, depending on which you selected to visualize) to eliminate less relevant heat map rows where no analysis meets the filter cutoff. The Upstream Regulator and Causal Network heat maps additionally enable filters on which type of upstream regulators (i.e. molecule types) appear in the heat map which allows a focus of the comparison on a particular kind of regulator, such as microRNAs, transcription factors, or chemicals.
Click on any heat map square to visualize the relevant network of genes. In the case of Downstream Effects Analysis (i.e. predicted increases or decreases to Bio Functions and Tox Functions), the network shows the genes in the particular analysis that have a causal or correlative relationship with the disease or function and indicates how they might increase or decrease the disease or function.
Causal Network Analysis is available at an additional cost.