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IPA-Tox is a capability within IPA
that delivers a focused toxicity and
safety assessment of candidate compounds.
- Enables assessment of the toxicity
and safety of compounds early in the
development process.
- Provides expert molecular toxicology
data interpretation to non-expert
users.
- Reveals clinical pathology endpoints
associated with a dataset.
- Generates new hypotheses that may
not have been revealed using traditional
toxicology approaches.
- Elucidates mechanism of toxicity
and identify potential markers of
toxicity.
- Allows access to important findings
from the scientific literature, including
information associated with cardiovascular
toxicity, nephrotoxicity, and hepatotoxicity.
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- Analysis Summaries:
Create an automated, focused, summarized
output of toxicology and safety data
for compounds under evaluation.
- Toxicity Lists:
Enable clear mechanistic analysis
of xenobiotic insult. The lists are
comprised of functional gene groupings,
based on critical biological processes
and key toxicological responses such
as adaptive, defensive, or reparative
responses to xenobiotic insult.
- Toxicity Functions:
Link expression data to clinical pathology
endpoints for mechanistic hypothesis
generation and identification of mechanism
of toxicity. Toxicity Functions cover
a wide spectrum of well-known drug
induced injuries and pathologies useful
for the drug discovery and development
process.
- Toxicity Lists and Toxicity
Functions can be combined
to understand pharmacological response,
mechanism of action, and mechanism
of toxicity.
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Analysis Summaries for Toxicology
Analysis Summaries create an automated and
focused output of toxicity and safety data
for compounds under evaluation.
Toxicity Lists
Toxicity Lists enable mechanistic analysis
of xenobiotic insult and help researchers
rapidly understand biological responses in
the liver, kidney, or heart. Toxicity Lists
are comprised of molecular toxicity pathways
and gene lists. These unique groupings are
based on critical biological processes and
key toxicological responses such as adaptive,
defensive, or reparative responses to xenobiotic
insult.
Toxicity Lists Features
- Manually-curated by Ph.D. scientists
- Relevant to drug metabolism
- Cover oxidative stress response
- Include panel of P450’s, xenobiotic
metabolism
- Relevant to hepatic, renal, and cardiac
toxicity and function
- Contain fibrosis, cardiac hypertrophy
and cell death
Toxicity Functions
Toxicity Functions link expression data to
clinical pathology endpoints for mechanistic
hypothesis generation. Categories cover a
wide spectrum of well known drug induced injuries
and pathologies useful for the drug discovery
and development process, such as:
- Hepatoxicity
- Steatosis, Necrosis, Fibrosis, and more
- Cardiotoxicity
- Cardiomyopathy, cardiac dilation, fibrosis
- Nephrotoxicity
- Tubular nephrosis, Phospholipidosis,
kidney weight increase, and more
Toxicity Functions link data to phenotypic
endpoints.
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