Bioinformatics Infrastructure and Content

For bioinformaticians, cheminformaticians, and computational biologists, accelerate the ability to design, test, and deploy cutting edge network and predictive inference algorithms with Ingenuity Informatics Content and Infrastructure.

Power your computational algorithms and inference models with the industry's leading knowledge base of manually curated, high quality, structured findings

• The Ingenuity Pathways Knowledge Base of highly structured and computable findings expertly extracted from the scientific literature provides a unique foundation with which to power new algorithmic approaches to life sciences research.

Increase your algorithmic capabilities by leveraging the structure of the Ingenuity Ontology

• The richness and structure of the Ingenuity Ontology provides an unsurpassed range of computational flexibility and predictive inference capabilities.

Accelerate your development by partnering with Ingenuity’s expert computational biology staff

• Ingenuity's computational biology team has decades of experience in the development and deployment of novel algorithmic approaches, and works in close partnership with key pharmaceutical customers to develop and test innovative approaches that take full advantage of Ingenuity technology.

Quickly test and deploy new algorithms and approaches

• Ingenuity partners closely with informatics organizations to enable rapid prototyping, and structures relationships to reflect the evolving needs of your organization.

PRODUCTS AND SERVICES INCLUDE

Knowledge Bases:
For research groups developing their own computational approaches and solutions for network analysis and computational inference, Ingenuity provides specialized content extractions of the Ingenuity knowledge base.  The customized knowledge bases are updated with new findings from the literature on a regular basis.  Types of content available include:

• Physical and functional relationships between genes, proteins, and chemicals
• Disease associations
• Gene focused events
• Chemical focused events
• Molecules
• Annotations

ASK Query Language:
ASK facilitates the search and retrieval of complex data by facilitating powerful queries and answering complicated scientific questions.  User-defined Ask Wizards (macros) are available to provide access to content without requiring complete understanding of ontology models.
Here are some examples of questions you can answer using ASK:

• Which genes increase apoptosis of cancer cells? 
• Which genes decrease apoptosis of cancer cells?
• What genes are expressed in the particular cell lines that I’m using in my experiments?
• What is the phosphorylation state of my protein of interest when it activates downstream genes? 

APIs:
Through application programming interfaces (APIs), execute key IPA features from in-house or third party applications to streamline workflows and accelerate internal development projects.

• Share IPA results with colleagues via email
• Integrate corporate web portals with IPA
• Create interactive reports