Customized Collaboration Workspace

• Facilitate collaboration within specific teams or consortia by setting up a customized Collaboration Workspace - project-specific information is accessible only by designated team members.
• Leverage read/write protections to explore and iterate on analyses, datasets, and custom Lists or Pathways in the workspace, while ensuring that the original files, hypotheses and insights are not overwritten.
• Take advantage of increased support for project teams, individual academic or commercial labs, groups of labs collaborating on a large grant, and groups that need to disseminate datasets and analyses to their downstream customers.

Locate Reagents From Within IPA

• IPA Reagent View^beta lets you easily locate reagent information for genes in your experimental system within IPA, providing timely access to necessary information without costly disruptions to your thought process and workflow.
  • Access Reagent View through Search or within the context of interactive Pathways and Networks
  • Reagent information is mapped to the knowledge structure in the Ingenuity Knowledge Base for more targeted and integrated results
• Quickly design validation experiments to test hypotheses within specific experimental parameters.
  • Find reagents by application (siRNA, small molecule inhibitors/agonists, antibody, gene expression primers, etc)
  • Find reagents by species (human, mouse, rat, primate)
  • Find reagents by leading vendors (Applied Biosystems™, BD Biosciences, Millipore™, ThermoFisher, and Sigma-Aldrich^®)
• Directly link from your gene or protein of interest in IPA to vendor websites to access additional life science reagents information or place an order.

Clinical Trial Information

• Explore expanded clinical trial drug information, including drugs and drug candidates in early human studies (Phase 0) and in post-market studies for alternative indications or long term safety assessment (Phase IV).
• Access clinical trial records in the Ingenuity^® Knowledge Base for over 2300 drugs and drug candidates.
• Chem Views, Gene Views, Drug Overlay features and Drug Summaries enable integration of therapeutically relevant knowledge within any Pathway or Network context in IPA.
• Understand competitive efforts by accessing Clinical Trial records and leveraging the structure of the Ingenuity Knowledge Base to establish connections between drugs, their targets, and clinical trial details including Indication, Phase, Trial Status, and Sponsor.

New Pathways and Disease Findings

• New Influenza-related pathways
  • Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
  • Role of MAPK Signaling in the Pathogenesis of Influenza
  • Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
  • Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza
  • Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
• New immunology-related pathways:
  • TNFR1 Signaling
  • TNFR2 Signaling
  • PKCθ Signaling in T Lymphocytes
  • Nur77 Signaling in T Lymphocytes
  • TWEAK Signaling
• New clinical biomarker content
  • Includes new biomarker to disease relationships, ~500 new biomarker molecules, and ~25 new drugs