Dynamically Generated Pathway & List Reports

• Understand the broader biological and therapeutic relevance of a particular pathway or gene list by generating reports with detailed summaries and tables describing:
• Pathway Function
• Top 3 Related Biological Processes
• Drugs that target pathway members
• Targets in the pathway
• Generate custom reports for any MyPathway or MyList in IPA:
• Customer uploaded lists
• Gene Lists generated from IPA searches for diseases, processes

Weekly Content Updates

• Get immediate access to Findings added to the Ingenuity Knowledge Base each week
• Easily refresh Networks and My Pathways with molecular interactions and regulatory events recently added to the Ingenuity Knowledge Base
• Weekly content updates to Gene Views and Chem Views highlight recent developments in your field

Clinical Biomarkers

• Over 1200 genes, transcript, protein, and metabolite biomarkers used in clinical settings are now available in IPA
• These clinical biomarkers have been used for a range of applications relevant to over 190 diseases
• Identify biomarkers by their specific application, including markers for Disease Diagnosis and Prognosis, Disease Progression, markers of Drug Efficacy and Safety, and Patient Response to Therapy
• Gain confidence at various decision points in your Biomarker Discovery and Validation programs by identifying clinical biomarkers during data analysis, pathway building, list filtering, and search workflows
  
  

Improved Pathway Generation/Exploration Tools

• New Network Size parameters enable you to build larger networks, consolidating key molecular events and highlighting central regulatory molecules
• Date Range Filters customize networks to highlight more recent discoveries

New Pathways and Findings:

• Nine New Disease Pathways, including:
• HER-2 Signaling in Breast Cancer
• Hereditary Breast Cancer Signaling
• Estrogen-Dependent Breast Cancer Signaling
• Ovarian Cancer Signaling
• Atherosclerosis Signaling
• Leptin Signaling in Obesity
• Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
• Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
• Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
• Six New Signaling Pathways including:
• PAK Signaling
• Phospholipase C Signaling
• Protein Kinase A Signaling
• Rac Signaling
• RhoA Signaling
• Regulation of eIF4 and p70S6K Signaling
• Updates to protein-protein interaction content from INTACT, BIOGRID, MINT and DIP databases
• Additional Findings for CNS Disorders including schizophrenia and bipolar disorders

Learn more about how IPA helps in disease research by clicking here.
Full release notes are available in the help section of IPA.

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