Details

Metabolite content from the Human Metabolome Database (HMDB):

The Human Metabolome Database (HMDB, http://www.hmdb.ca/) contains high-quality detailed information about small molecule metabolites found in the human body. Ingenuity has integrated the findings from this database into the Ingenuity Knowledge Base, with a specific emphasis on the following findings:

• Metabolite detection in biofluids: Over 11,000 findings describing the localization of 3,600 metabolites in biofluids from normal adults, as well as patients with a specific disease. Findings include details about metabolite concentration, and gender of the patient.
• Metabolite subcellular localization: Over 5,200 findings that predict subcellular localization information for 4,300 metabolites.
• Metabolite tissue localization: Over 4,400 findings that describe detection of 2,000 metabolites in normal tissues.

This metabolite content will enhance the Contextual Data Analysis features in IPA by enabling you to identify key subsets of metabolites your pathways and networks based on their detection in a particular biofluid or tissue.

New drug-to-disease knowledge from DrugBank and Clinicaltrials.gov:

Additional drug-to-disease knowledge supports drug mechanism of action and mechanism of toxicity studies.

• Additional content from Clinicaltrials.gov (http://clinicaltrials.gov/) has been structured and modeled in the Ingenuity Knowledge Base, including:
• 700 new relationships between clinical candidates and the diseases and indications they have been developed for
• Updated clinical trial status and drug approval information
• Drug information from DrugBank (http://www.drugbank.ca/) including 300 new relationships between approved drugs and diseases, and 15,000 new brand names added as synonyms to the Ingenuity Knowledge Base.

Additional Content in Key Therapeutic Areas, including:

• Alzheimer’s Disease
• 14,000 new findings from over 800 articles including 1,300 gene-to-disease associations involving 250 genes
• Infectious Disease/Immune Response
• New pathways outlining mechanisms of cellular immune response signaling
• Oncology
• New pathways for Colorectal Cancer Metastasis Signaling and Pancreatic Adenocarcinoma Signaling

Expansion of Pathway Library:

Twenty-two pathways have been added: 19 new signaling pathways in the areas of cellular immune response, intracellular and second messenger signaling, cellular proliferation and development, apoptosis, and cellular stress and injury, as well as three new disease pathways related to oncology and autoimmune disease.

Signaling Pathways:

AMPK Signaling
April Mediated Signaling
Cdc42 Signaling
Cleavage and Polyadenylation of Pre-mRNA
Communication between Innate and Adaptive Immune Cells
Crosstalk between Dendritic Cells and Natural Killer Cells
EIF2 Signaling
ERK5 Signaling
FAK Signaling
GΒγ Signaling
G Protein Signaling Mediated by Tubby
Gα12/13 Signaling
ILK Signaling
mTOR Signaling
Myc Mediated Apoptosis Signaling
p70S6K Signaling
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
Retinoic acid Mediated Apoptosis Signaling
Sphingosine-1-phosphate Signaling

Disease Pathways:

Colorectal Cancer Metastasis Signaling
Pancreatic Adenocarcinoma Signaling
Systemic Lupus Erythematosus Signaling

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