"The goal of our study was to provide knowledge about intracellular signaling events in glioma cancer stem cells in response to perturbations by hypoxia, inhibition of STAT3 phosphorylation and IL-6 stimulation. Glioma cancer stem cells (gCSC) are refractory to traditional therapies and new insights are needed to understand their underlying biology. We used IPA to compliment our analysis of multiple comparisons between gCSC treatments. We will continue to employ IPA tools in analysis of global phosphoproteomic data sets."
– Charles Conrad, M.D.
Professor, Department of Neuro-Oncology
The University of Texas M. D. Anderson Cancer Center
See how IPA was used in this publication:
Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells.
Nilsson CL, Dillon R, Devakumar A, Shi SD, Greig M, Rogers JC, Krastins B, Rosenblatt M, Kilmer G, Major M, Kaboord BJ, Sarracino D, Rezai T, Prakash A, Lopez M, Ji Y, Priebe W, Lang FF, Colman H, Conrad CA. J Proteome Res. 2010 Jan;9(1):430-43.
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