Ingenuity customer Meredith Prysak, Ph.D. (Aestus Therapeutics) will lead a scientific webinar entitled “Utilizing IPA for the Discovery and Development of New Pain Therapeutics” on Wednesday, September 14th.
In the United States, more than 39 million people suffer from neuropathic pain related to postherpetic neuralgia, trigeminal neuralgia, AIDS-related neuropathy, diabetic neuropathy, chronic low back pain, and cancer neuropathy. Unfortunately, neuropathic pain is often intractable and resistant to available drug therapies, none of which achieve clinical significance greater than 50%. To address this problem of great clinical need and poor therapeutic response, new mechanisms of action must be identified for future pain therapeutics. Aestus Therapeutics has undertaken a project to identify novel biological pathways involved in neuropathic pain using genome-wide expression data from a variety of sources and models. IPA (as well as other bioinformatics tools) helped Aestus identify seven novel biological pathways previously not associated with neuropathic pain. These seven novel pathways are being targeted for novel pain therapies. These potential therapeutics have been pre-clinically tested in animal models, validating both the pathways and the targets. The lead compound for the project, ATx08-001, was recently advanced into the clinic by Aestus, and is currently in a Phase 2 trial for the treatment of post-herpetic neuralgia. In this presentation, you will see how IPA was used to filter and explore existing data to investigate affected pathways and ultimately pathways for novel neuropathic pain therapies for patients.
Register to attend this webinar on Wednesday, September 14. Engage with Ph.D. scientists across the globe that are working with IPA and neuroscience data, and learn how to utilize IPA to discover your targets faster and validate previous results.
- Wednesday, September 14, 10 am Pacific (1 pm EDT, 6 pm BST)
View our entire schedule of scientific 2011 webinars.
Watch Dr. Prysak’s pre-recorded talk:
Dr. Prysak presented a version of this talk in June in New Jersey at the Ingenuity Customer Showcase Seminar. At this event, scientists educated peers on how they have utilized IPA for their research discovery. Ingenuity has hosted two customer showcase seminars in 2011, in New Jersey and Massachusetts.
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