Featured Researcher, Dr Lydia Aschuer: Biomarkers for Nephrotoxicity

Lydia AschauerIn our last blog, we talked about featuring some of the scientist’s contributions to science using QIAGEN’s Ingenuity Products. This month, our featured researcher is Dr. Lydia Aschuer.

Lydia Aschuer is a scientist at the Innsbruck Medical University (IMU) in Austria.  She and her colleagues are researching better predictive models for human drug and chemical safety, and to advance biomarker discovery.

Aschuer’s team, based in the lab of nephrology expert Paul Jennings, are studying how chemical and environmental stressors affect cultured human kidney cells. These organs are particularly vulnerable to damage from medications and other chemicals and can be compromised or shut down completely by such exposure.

“The kidney has a critical job in keeping us healthy,” says Aschauer.  “The more we understand how it processes different chemicals and compounds and how those things affect it, the better equipped we’ll be to treat and care for this vital organ.”

Aschauer and her colleagues think that compound induced cell stress and toxicity likely compromise normal kidney function as a consequence of cell differentiation related to their response to toxins. To test this hypothesis, they have developed a maturation data set evaluating kidney function over time that they are comparing to nephrotoxin-induced molecular signatures.

Powering the lab’s research are molecular assays and state-of-the-art technologies that generate transcriptomic, proteomic, and metabolomic data. By integrating all this information together with high-value analysis tools, the IMU team is assembling a more global view of how nephrotoxins impact the mechanisms underlying kidney function and dysfunction.

To bring these seemly disparate data sets together, Aschauer and her colleagues have chosen QIAGEN’s Ingenuity IPA platform. To read more about Dr. Ashauer’s work please read the case study in our Features Researcher section.

We would like to take this opportunity to invite you (scientists and researchers) to contact us if you have a scientific story you would like us to share with the community. It will not only give you an opportunity to share your work with our research community, foster collaboration, highlight your published research but also increase your visibility in the research community.