Dana Abramovitz, Product Manager at Ingenuity Systems, will present Thursday February 24, 2011 at the Molecular Medicine Conference in San Francisco, CA. Dana will talk about using IPA software from Ingenuity Systems to explore microRNA impacts on molecular mechanisms of disease, exploring the role of microRNA in several diseases and expanding on findings using new functionality in IPA .
Everyone is trying to understand microRNAs and how they regulate gene expression. How do they impact the mRNAs they target? How do they influence downstream biological consequences, such as the perturbation of key pathways and disease processes? How can you better understand these questions using gene expression data?
We’ll be discussing these topics and more at the 2011 Molecular Medicine Conference in San Francisco. Please join us on Thursday, 2/24/11, 12:30 PM for our discussion:
Using IPA to explore microRNA impacts on molecular mechanisms of disease
Dana Abramovitz, Product Manager, Ingenuity Systems
We’ll talk about researchers’ need to identify interactions between microRNAs and mRNAs, both predicted and experimentally validated, and to prioritize those mRNAs that are most relevant to the biological system they are studying. Some researchers have defined an approach that uses the predicted binding of microRNAs to mRNA targets from databases such as TargetScan, along with expression data, to create a list of candidate mRNA targets which are subsequently analyzed using various bioinformatics methods and tools to uncover biological relevance. We will highlight how several authors have used IPA to apply this approach to explore the role of microRNA in several diseases including melanoma, breast cancer, and prion-induced neurodegeneration. We will expand on their findings using new functionality in IPA that enables interactive identification, prioritization and analysis of microRNAs and their targets and visual exploration of the resulting interactions.
Visit us at Booth 307 to learn more about how IPA can provide valuable biological interpretation of your experimental data.
Special offer: Friends of Ingenuity can receive a discount on your Mol Med registration. Use the code 1137IG to register to receive $150 off commercial registrants or $75 off academic registrants.