Ingenuity's Path Designer is Selected as Best New Product By Life Science Community at 2008 Molecular Medicine Conference

Ingenuity Systems and Pfizer Announce Strategic Partnership for Pathway Analysis

Ingenuity Systems Delivers Key Milestones in FDA Collaboration to Facilitate Genomic Data Review

Ingenuity Systems Extends Enterprise-Level Software Agreement With GlaxoSmithKline

Ingenuity Releases Newest Version of IPA with Pathway Publishing Tool

Read the GEN article on how IPA facilitates the biomarker discovery process

Transcriptional Networks Inferred from Molecular Signatures of Breast Cancer

Am J Pathol. 2008 Feb;172(2):495-509. Epub 2008 Jan 10

Researchers from various departments at the National Cancer Institute, Bethesda, Maryland, in collaboration with several universities used Ingenuity Pathways Analysis to identify networks that appeared most associated with the regulatory signatures found in the promoters of five different molecular sub types of breast cancer. The regulatory signatures were defined as an assembly of transcription factor binding sites (TFBSs) found to be non-randomly shared by several genes associated with a molecular phenotype. One of the networks associated with a particular subtype (ERBB2) identified a novel role for NF-kB and ERBB2 in a self amplifying, auto regulatory module. The existence of this pathway was then empirically validated.

» Link to article synopsis
» Search Publications